A new protocol based on the i/m administration of insulin lispro was shown to be effective and safe for the treatment of DKA in dogs but further studies are required to validate the treatment protocol
Journal citation

Malerba. E., Alessandrin.i F., Grossi G., et al (2020)
Efficacy and Safety of Intramuscular Insulin Lispro vs. Continuous Intravenous Regular Insulin for the Treatment of Dogs With Diabetic Ketoacidosis
Frontiers in Veterinary Science; 7: 559008
Abstract

Published October 2020

Type of study
  • Non-randomised controlled trial
  • n = 24
Key points
  • Aim of the study was to compare the safety and efficacy of a new diabetic ketoacidosis (DKA) protocol based on i/m administration of insulin lispro (group L) with that of low dose constant rate infusion (CRI) of regular canine insulin (group R) in dogs
  • Insulin lispro is rapid acting due to its structure
  • No adverse effects were associated with insulin protocols in either group
  • The median time to resolution of hyperglycaemia and the length of hospitalisation was similar in both groups but the median time to resolution of the ketosis was significantly shorter in group L (12 hours) compared to group R (23 hours)

Limitations

  • Small number of cases
  • Lack of randomisation
  • Different comorbidities may have interfered with the response to the treatment protocols
  • Other treatments e.g. type of fluids were not standardised
  • Two different portable glucometers were used which may have affected results
Conclusions
  • The results of this study demonstrate that a new protocol based on the i/m administration of insulin lispro was effective and safe for the treatment of DKA in dogs but further studies are required to validate the treatment protocol